Acetic Acid → HCID 89494514, Verbindung
Reaktionsgleichung
C(S[C:4]1[NH:5][C:6](=[O:14])[C:7]2[CH2:12][S:11][CH:10]([CH3:13])[C:8]=2[N:9]=1)C.Cl.CC(O)=[O:18]>O>[CH3:13][CH:10]1[C:8]2[NH:9][C:4](=[O:18])[NH:5][C:6](=[O:14])[C:7]=2[CH2:12][S:11]1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a suspension of 2-(ethylthio)-7-methylthieno[3,4-d]pyrimidin-4(3H,5H,7H)-one (3.96 g, 17.3 mmol) in water (20 mL) was added 2.0 mL of conc. HCl and 4.0 mL of AcOH. The mixture was heated to reflux overnight then cooled and the precipitated solid collected by filtration, washed with water and methanol, evaporated and dried to obtain 7-methylthieno[3,4-d]pyrimidine-2,4(1H,3H,5H,7H)-dione as a white solid (2.52 g, 80%). Without further purification, the crude product was used directly in the next step.
Aufarbeitung
- temperatureThe mixture was heated
- temperatureto reflux overnight
- temperaturethen cooled
- filtrationthe precipitated solid collected by filtration
- washwashed with water and methanol
- customevaporated
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-0a4dc8363f3044749f2618383848e550
- Quelldatensatz
- uspto-grants-2016_01
- Patentnummer
- US09242993B2
Notizen zur Reaktion
Wird geladen…