Diisopropylamine → (R)-6-fluoro-3,3-dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one

HRID 59680

Reaktionsgleichung

Reaktionsgleichung von HRID 59680
C(NC(C)C)(C)C.[Li]CCCC.[CH3:13][C:14]1([CH3:23])[N:18]2[C:19](=[O:22])[CH2:20][CH2:21][C@@H:17]2[CH2:16][O:15]1.C1C=CC(S(N(S(C2C=CC=CC=2)(=O)=O)[F:34])(=O)=O)=CC=1>C1COCC1.C(OCC)(=O)C>[F:34][C@H:20]1[C:19](=[O:22])[N:18]2[C:14]([CH3:23])([CH3:13])[O:15][CH2:16][CH:17]2[CH2:21]1

Komponenten

7

Edukt 4

HCID 7912DiisopropylamineHCID 588007N-FluorobenzenesulfonimideHCID 137469293H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3,3-dimethyl-, (R)-2×HCID 178418339Butyllithium

Produkt 1

HCID 118160165(R)-6-fluoro-3,3-dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel3×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a mixture consisting of diisopropylamine (6.5 mL, 46 mmol) and THF (75 mL) at −78° C. was added dropwise a solution of nBuLi (2.5 M in hexanes, 18 mL, 44 mmol), and the resulting solution stirred for one hour. A solution consisting of (R)-3,3-dimethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one (intermediate 4, 3.6 g, 23 mmol) in THF (25 mL) was added dropwise, and the resulting solution stirred for one hour. A solution consisting of N-fluorobenzenesulfonimide (9.5 g, 30 mmol) in THF (50 mL) was added dropwise, and the resulting solution was allowed to stir for 75 minutes below −55° C., and was subsequently quenched with the addition of a saturated aqueous ammonium chloride solution and warmed to room temperature. The organic material was extracted twice with ethyl acetate. The combined organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was dissolved in ethyl acetate, filtered, and the filtrate was concentrated to a gold oil, which was purified by silica gel chromatography. Elution with ethyl acetate:heptanes (1:3 v/v) afforded an approximately 1:1 mixture of the diastereomers of the title intermediate (1.54 g) as a clear oil; TLC Rf 0.40 (solvent system 50:50 v/v heptanes:ethyl acetate); 1H-NMR (CDCl3) δ 5.4-5.2 (m, 1H), 5.2-5.0 (m, 1H), 4.5-4.4 (m, 1H), 4.2-4.1 (m, 2H), 4.0-3.9 (m, 1H), 3.5 (t, 1H), 3.4 (t, 1H), 2.8-2.7 (m, 1H), 2.5-2.3 (m, 1H), 2.1-1.8 (m, 2H), 1.7 (s, 3H), 1.7 (s, 3H), 1.5 (s, 3H) 1.5 (s, 3H); 19F-NMR (CDCl3, 376 MHz) δ −102.2 (dd, ˜0.5F, J=264.2, 13.2 Hz), ˜103.5 (ddd, ˜0.5F, J=264.3, 26.5, 14.6 Hz); MS (ESI+) m/z 174.1 (M+1).

Aufarbeitung

  1. additionwas added dropwise
  2. stirringthe resulting solution stirred for one hour
  3. additionwas added dropwise
  4. stirringto stir for 75 minutes below −55° C.
  5. customwas subsequently quenched with the addition of a saturated aqueous ammonium chloride solution
  6. extractionThe organic material was extracted twice with ethyl acetate
  7. dry with materialThe combined organic phase was dried over anhydrous sodium sulfate
  8. filtrationfiltered
  9. concentrationconcentrated
  10. dissolutionThe residue was dissolved in ethyl acetate
  11. filtrationfiltered
  12. concentrationthe filtrate was concentrated to a gold oil, which
  13. customwas purified by silica gel chromatography
  14. washElution with ethyl acetate:heptanes (1:3 v/v)
  15. customafforded

Quellen und Nachweise

ORD-Eintrag
ord-2b03da8941b54cd4bb274a7a8e8a54f4
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440919B2

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