Bromoacetyl bromide → 1-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline

HRID 597705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 597705
[Br:1][CH2:2][C:3](Br)=[O:4].[NH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1>C1C=CC=CC=1>[Br:1][CH2:2][C:3]([N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)=[O:4]

Komponenten

4

Edukt 2

HCID 61147Bromoacetyl bromideHCID 694601,2,3,4-Tetrahydroquinoline

Produkt 1

HCID 5838141-(Bromoacetyl)-1,2,3,4-tetrahydroquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 20.2 g. of bromoacetyl bromide in 150 ml. of benzene is added dropwise over 30 minutes, 26.6 g. of 1,2,3,4-tetrahydroquinoline dissolved in 35 ml. of benzene. The reaction mixture is then stirred at room temperature for 18 hours, after which time the precipitate is filtered off. The resultant filtrate is washed successively with 1N HCL solution and with a saturated sodium chloride solution, dried, and the solvent removed under reduced pressure to yield 1-(bromoacetyl)-1,2,3,4-tetrahydroquinoline, b.p. 70°-80° C. (at 0.1 mm. Hg).

Aufarbeitung

  1. filtrationafter which time the precipitate is filtered off
  2. washThe resultant filtrate is washed successively with 1N HCL solution and with a saturated sodium chloride solution
  3. customdried
  4. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ce6c420f2dd44392ad412c7d98e22342
Quelldatensatz
uspto-grants-1977_03
Patentnummer
US04015005

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