Water → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinic acid

Temperatur

70 °C

5-Bromo-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinic acid ethyl ester (2 g, 5.05 mmol) was dissolved in ethanol (30 ml). To this solution was added with stirring [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II) CH2Cl2 (41.2 mg, 0.05 mmol), 4-chlorophenylboronic acid (828.8 mg, 5.3 mmol), water (4.8 ml) and lithium hydroxide (246.7 mg, 10.1 mmol). This mixture was heated to 70° C. for 2.5 h and cooled to room temperature. Water (12 mL) and lithium hydroxide (370.0 mg, 15.1 mmol) was added and stirred at 70° C. for 0.5 h. The reaction mixture was cooled to room temperature, treated with water (40 ml) and toluene (40 ml) and extracted. The phases were separated, the organic phase extracted with water (30 ml). The combined water phase was acidified with HCl 2N and extracted with ethylacetate. Organic phases were pooled, dried with Na2SO4 and the volatiles removed in vacuo. The residue was dissolved in ethanol (6 ml) and treated with water (12 ml) to give after crystallization the title compound (1.82 g) as light brown crystals; MS (ISN) 398.0 (M−H)−.

1. temperaturecooled to room temperature
2. temperatureThe reaction mixture was cooled to room temperature
3. extractionextracted
4. customThe phases were separated
5. extractionthe organic phase extracted with water (30 ml)
6. extractionextracted with ethylacetate
7. dry with materialdried with Na2SO4
8. customthe volatiles removed in vacuo
9. dissolutionThe residue was dissolved in ethanol (6 ml)
10. additiontreated with water (12 ml)
11. customto give
12. customafter crystallization the title compound (1.82 g) as light brown crystals

ORD-Eintrag

ord-77078c99733a4fe9b2e7c729141e0d24

Quelldatensatz

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07897621B2