Hydrochloric Acid → 2(3H)-Benzothiazolethione, 6,7-dichloro-

HRID 598514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 598514
[Cl:1][C:2]1[C:3](F)=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].CCO[C:14]([S-:16])=[S:15].[K+].Cl>CN(C)C=O.O>[Cl:9][C:8]1[CH:7]=[CH:6][C:4]2[N:5]=[C:14]([SH:16])[S:15][C:3]=2[C:2]=1[Cl:1]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 2735045Potassium ethylxanthateHCID 27827033,4-Dichloro-2-fluoroaniline

Produkt 1

HCID 1785277912(3H)-Benzothiazolethione, 6,7-dichloro-Ausbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

A mixture of 1.5 g (8.33 mmol) 3.4-dichloro-2-fluoroaniline and 1.64 g (10.00 mmol) potassium ethylxanthogenate in 8 mL dry N,N-dimethylformamide was heated in a 95° C. oil bath for 5 h. The reaction mixture was cooled to room temperature and diluted with water (25 mL). The mixture was acidified with aqueous HCl 2N. The precipitate was collected by filtration, washed with water and dried to provide 1.8 g (92%) of the title compound as a white solid. MS(m/e): 233.8 (M−H+).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-88f96fc5bfa742dfbcd4c125c62a6cc8
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897627B2

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