Pyridine → N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide

HRID 60380

Reaktionsgleichung

Reaktionsgleichung von HRID 60380
[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.N1C=CC=CC=1>O>[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 885792-Pyridinamine, 5-iodo-

Produkt 1

HCID 21772024N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamideAusbeute 86,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 5-iodopyridin-2-amine (25.5 g), 4-methylbenzene-1-sulfonyl chloride (23.2 g) and pyridine (250 mL) was stirred at 100° C. overnight. The reaction mixture was poured into water (1.2 L) and stirred. The resulting solid was collected by filtration. The obtained solid was washed with water and diethyl ether and dried in vacuo to give the title compound (37.4 g) as a white solid.

Aufarbeitung

  1. stirringstirred
  2. filtrationThe resulting solid was collected by filtration
  3. washThe obtained solid was washed with water and diethyl ether
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2f3fa683d20e43d580c697040c92e7b9
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440987B2

Verknüpfte Notizen

Wird geladen…