Hydrochloric Acid → 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

HRID 60571

Reaktionsgleichung

Reaktionsgleichung von HRID 60571
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86680841Methyl 5-methyl-2-(pyridin-4-yl)benzoate

Produkt 1

HCID 866808425-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of methyl 5-methyl-2-(pyridin-4-yl)benzoate (8.8 g), 6 N hydrochloric acid (65 mL) and acetic acid (100 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained solid was washed with ethyl acetate to give the title compound (6.6 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained solid was washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-af2844a64cfa403e89abd8269f3bd4d6
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440990B2

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