4-Chloroanisole → 4-Methoxybiphenyl
Reaktionsgleichung
COc1ccc(Cl)cc1.OB(O)c1ccccc1>C1=C\CC/C=C\CC/1.C1=C\CC/C=C\CC/1.C1COCCO1.CC(C)(C)P(C1CCCCC1)C(C)(C)C.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Ni]>COc1ccc(-c2ccccc2)cc1Komponenten
8
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 5
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Aufarbeitung
- additionDilute with acetonitrile
- aliquotKeine Vorschrift aufgezeichnet
- customDiluent solution was made in 1 L batches with 950 mL acetonitrile, 25 mL water, 25 mL glacial acetic acid, and 53 mg 4,4’-di-tert-butylbiphenyl as an external standard (0.2 equiv standard per reaction). Aliquot taken from each well (47 ul) is added into 753 ul of diluent solution
Quellen und Nachweise
- ORD-Eintrag
- ord-846c819274b849c5a76189f2d3f825b5
- Quelldatensatz
- Ni-catalyzed Suzuki Miyaura cross-coupling
- Originallink
- Quelle ansehen
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