L-Glutamine → 2',3'-Didehydro-2',3'-dideoxycytidine

HRID 611473

Reaktionsgleichung

Reaktionsgleichung von HRID 611473
[CH3:1][C:2]1(C)S[C@@H]2[C@H](NC(CC3C=CC=CC=3)=O)[C:8](=[O:9])[N:4]2[C@H:3]1C([O-])=O.[K+].C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H]([NH:40]C(N)=N)[C@@H](O)[C@@H]2NC(N)=N)[C@H](O[C@@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2NC)[C@@]1(O)C=O.N[C@H:66]([C:72]([OH:74])=O)[CH2:67][CH2:68][C:69](=[O:71])[NH2:70]>>[C@@H:69]1([N:70]2[CH:1]=[CH:2][C:3]([NH2:40])=[N:4][C:8]2=[O:9])[O:71][C@H:66]([CH2:72][OH:74])[CH:67]=[CH:68]1

Komponenten

4

Edukt 3

HCID 5961L-GlutamineHCID 23664709Penicillin G PotassiumHCID 178484872HCID 178484872, Verbindung

Produkt 1

HCID 646832',3'-Didehydro-2',3'-dideoxycytidine

Versuchsvorschrift

Nucleoside Analogs: One millimolar solutions were prepared in glass distilled water and filter sterilized through 0.2μ filters. Subsequent dilutions were prepared in RPMI 1640 medium containing 15% fetal calf serum, penicillin, streptomycin and glutamine.

Aufarbeitung

  1. distillationdistilled water
  2. filtrationfilter
  3. customSubsequent dilutions were prepared in RPMI 1640 medium

Quellen und Nachweise

ORD-Eintrag
ord-b91f49ded366413b9e1ec08e9f999e10
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06001818

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