Water → 2-Methoxy-6-(trifluoromethyl)benzoic acid

HRID 611720

Reaktionsgleichung

Reaktionsgleichung von HRID 611720
[CH3:1][O-:2].[K+].F[C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8].O>CO>[CH3:1][O:2][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:6]=1[C:7]([OH:9])=[O:8]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6881232-Fluoro-6-(trifluoromethyl)benzoic acidHCID 23664618Potassium methoxide

Produkt 1

HCID 150175332-Methoxy-6-(trifluoromethyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of potassium methylate in methanol (15 ml, 15%) and 2-fluoro-6-trifluoromethylbenzoic acid (2.08 g, 0.01 mol) is heated to reflux with stirring for 40 hours. Upon cooling to room temperature water is added. The reaction mixture is filtered and the filtrate is acidified with concentrated hydrochloric acid. The solid material is collected by filtration, washed with water and dried yielding white crystals, 1.4 g (64%), mp 130-131° C.

Aufarbeitung

  1. temperatureis heated
  2. temperatureto reflux
  3. additionis added
  4. filtrationThe reaction mixture is filtered
  5. filtrationThe solid material is collected by filtration
  6. washwashed with water
  7. customdried
  8. customyielding white crystals, 1.4 g (64%), mp 130-131° C.

Quellen und Nachweise

ORD-Eintrag
ord-59a931e776544b77ae6ea1b472ab51c4
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06001883

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