Methanol → HCID 136404630, Verbindung

HRID 613348Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 613348
[BH4-].[Na+].C(Cl)Cl.CO.[CH:8]([C:10]1[CH:14]=[C:13]2[C:15]([C:73]3[CH:78]=[CH:77][CH:76]=[CH:75][C:74]=3[NH:79][C:80](=[O:85])[C:81]([CH3:84])([CH3:83])[CH3:82])=[C:16]3[N:20]=[C:19]([C:21]([C:60]4[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=4[NH:66][C:67](=[O:72])[C:68]([CH3:71])([CH3:70])[CH3:69])=[C:22]4[NH:26][C:25](=[C:27]([C:47]5[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=5[NH:53][C:54](=[O:59])[C:55]([CH3:58])([CH3:57])[CH3:56])[C:28]5[CH:29]=[CH:30][C:31](=[C:33]([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=6[NH:40][C:41](=[O:46])[C:42]([CH3:45])([CH3:44])[CH3:43])[C:11]=1[NH:12]2)[N:32]=5)[CH:24]=[CH:23]4)[CH:18]=[CH:17]3)=[O:9]>O>[OH:9][CH2:8][C:10]1[CH:14]=[C:13]2[C:15]([C:73]3[CH:78]=[CH:77][CH:76]=[CH:75][C:74]=3[NH:79][C:80](=[O:85])[C:81]([CH3:84])([CH3:83])[CH3:82])=[C:16]3[N:20]=[C:19]([C:21]([C:60]4[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=4[NH:66][C:67](=[O:72])[C:68]([CH3:69])([CH3:70])[CH3:71])=[C:22]4[NH:26][C:25](=[C:27]([C:47]5[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=5[NH:53][C:54](=[O:59])[C:55]([CH3:56])([CH3:57])[CH3:58])[C:28]5[CH:29]=[CH:30][C:31](=[C:33]([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=6[NH:40][C:41](=[O:46])[C:42]([CH3:43])([CH3:44])[CH3:45])[C:11]=1[NH:12]2)[N:32]=5)[CH:24]=[CH:23]4)[CH:18]=[CH:17]3

Komponenten

6

Edukt 4

HCID 887MethanolHCID 6344DichloromethaneHCID 4311764Sodium borohydrideHCID 16167393HCID 16167393, Verbindung

Produkt 1

HCID 136404630HCID 136404630, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

NaBH4 (41.5 mg, 1.1 mmol) was added to a solution of CH2Cl2 --MeOH (1/3 v/v) (8 ml) containing 2-formyl-5,10,15,20-tetrakis(o-pivalamidophenyl)porphyrin (0.11 g, 0.11 mmol) under argon stirred for 15 min. After adding water to the solution, the mixture was extracted by CHCl3 and washed with water. After drying (Na2SO4), the organic layer was chromatographed on a silica gel flash column using CHCl3 --MeOH (10/1 v/v) as the eluent. The residue was dried at room temperature in vacuo to give a purple product, (2-hydroxymethyl-5,10,15,20-tetrakis(o-pivalamidophenyl)porphyrin, 0.11 g, 94%).

Aufarbeitung

  1. extractionthe mixture was extracted by CHCl3
  2. washwashed with water
  3. dry with materialAfter drying (Na2SO4)
  4. customthe organic layer was chromatographed on a silica gel flash column
  5. customThe residue was dried at room temperature in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f438c2ec0f2d427da719100d28780c8b
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06008198

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