Cyanogen Bromide → 2,2-Dimethoxy-1-methylpropylcyanamide

HRID 615262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 615262
[N:1]#[C:2]Br.[CH3:4][O:5][C:6]([O:11][CH3:12])([CH3:10])[CH:7]([NH2:9])[CH3:8]>O.CO>[CH3:4][O:5][C:6]([O:11][CH3:12])([CH3:10])[CH:7]([NH:9][C:2]#[N:1])[CH3:8]

Komponenten

5

Edukt 2

HCID 10476Cyanogen BromideHCID 158518261-Methyl-2,2-dimethoxypropylamine

Produkt 1

HCID 201644792,2-Dimethoxy-1-methylpropylcyanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

Cyanogen bromide (424 mg., 4 m moles) was added to a solution of 2,2-dimethoxy-1-methylpropylamine (266 mg., 2 m moles) and KHCO3 (400 mg., 4 m moles) in a mixture of water (2 ml.) and methanol (4 ml.). After 15 minutes the mixture was poured into water (150 ml.) and the mixture extracted with CH2Cl2. The extract was washed with water and brine, dried (MgSO4) and evaporated to dryness to give 2,2-dimethoxy-1-methylpropylcyanamide as a pale yellow oil (280 mg., 88%) having the following n.m.r. spectrum in CDCl3 : 1.15 (s, 3H), 1.18 (d, 3H); 3.15 (s, 6H); 3.0-3.6 (m, 1H); 4.0 (m, 1H).

Aufarbeitung

  1. extractionthe mixture extracted with CH2Cl2
  2. washThe extract was washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-b33e2376a4334f72a40abad4790fb097
Quelldatensatz
uspto-grants-1985_02
Patentnummer
US04497949

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