Oxalyl chloride → 2-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride

HRID 615267

Reaktionsgleichung

Reaktionsgleichung von HRID 615267
C(Cl)(=O)C([Cl:4])=O.[F:7][C:8]([F:29])([F:28])[C:9]1[CH:27]=[CH:26][C:12]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20](O)=[O:21])=[CH:16][CH:15]=2)=[CH:11][CH:10]=1>CN(C)C=O.CCOCC>[F:7][C:8]([F:29])([F:28])[C:9]1[CH:27]=[CH:26][C:12]([O:13][C:14]2[CH:25]=[CH:24][C:17]([O:18][CH:19]([CH3:23])[C:20]([Cl:4])=[O:21])=[CH:16][CH:15]=2)=[CH:11][CH:10]=1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 181206Trifop

Produkt 1

HCID 129060152-{4-[4-(Trifluoromethyl)phenoxy]phenoxy}propanoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Oxalyl chloride (1.56 g, 1.1 ml, 12.32 mmol) is added to a stirring solution of 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid (2.00 g, 6.16 mmol), dimethylformamide (DMF; 4 drops) and ether (50 ml). The mixture is stirred at RT for 3 hours. Insoluble material is filtered off and solvent is removed in vacuo to give 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid chloride.

Aufarbeitung

  1. filtrationInsoluble material is filtered off
  2. customsolvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b22259dbd0674c5cbab84b9151c284b3
Quelldatensatz
uspto-grants-1985_02
Patentnummer
US04497965

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