Sulfamic Acid → 6-Arylpyrido[2,3-d]pyrimidine deriv. 42

HRID 617953

Reaktionsgleichung

Reaktionsgleichung von HRID 617953
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[CH:11]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[C:9]([NH2:20])=[N:8][C:6]=2[N:7]=1.S(=O)(=O)(O)N.N[CH2:27][CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[C:10]1[C:9]([NH2:20])=[N:8][C:6]2[N:7]=[C:2]([NH:1][CH2:27][CH2:28][CH2:29][N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[N:3]=[CH:4][C:5]=2[CH:11]=1

Komponenten

4

Edukt 3

HCID 5987Sulfamic AcidHCID 61055N-(3-Aminopropyl)morpholineHCID 53281136-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Produkt 1

HCID 53281446-Arylpyrido[2,3-d]pyrimidine deriv. 42

Versuchsvorschrift

A mixture of 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine (4.00 g) from Example 1, sulfamic acid (2.53 g) and aminopropylmorpholine (30 mL) was reacted as in Example 53. In this instance, the crude residue was washed with hot ethyl acetate followed by diethyl ether to afford 3.95 g of the title compound 6-(2,6-dichlorophenyl)-N2 -(3-morpholin-4-yl-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine, CIMS (1% NH3 in CH4): 461=M+ +C2H5, 433=M+ +H (Base), 346, 332; mp 224-230.5° C.

Aufarbeitung

  1. customwas reacted as in Example 53
  2. washIn this instance, the crude residue was washed with hot ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-2d04a73d0b2a474099260f098e5f5040
Quelldatensatz
uspto-grants-1999_09
Patentnummer
US05952342

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