Hydrazine hydrate (1:1) → 4-Hydrazinylpyridine-2-carbonitrile

HRID 61887

Reaktionsgleichung

Reaktionsgleichung von HRID 61887
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.O.[NH2:11][NH2:12]>O1CCOCC1.O>[C:8]([C:4]1[CH:3]=[C:2]([NH:11][NH2:12])[CH:7]=[CH:6][N:5]=1)#[N:9]

Komponenten

5

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 6933424-Chloro-2-pyridinecarbonitrile

Produkt 1

HCID 629251564-Hydrazinylpyridine-2-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-Chloro-2-cyanopyridine (1 g) was dissolved in hydrazine monohydrate (1 ml) and 1,4-dioxane (10 ml), and stirred overnight under reflux. The reaction solution was diluted with water (30 ml) and extracted repeatedly with ethyl acetate. The organic layer was concentrated to obtain the title compound as a crude product, which was used for the next step without further purification.

Aufarbeitung

  1. temperatureunder reflux
  2. extractionextracted repeatedly with ethyl acetate
  3. concentrationThe organic layer was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-930dc8f5cb434ba09836e381878fb8b4
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440922B2

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