Hydrazine hydrate (1:1) → 6-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 620205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 620205
[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=O)[CH2:21][CH2:22][C:23]([OH:25])=O)[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:28][NH2:29]>C(O)(=O)C>[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20]4[CH2:21][CH2:22][C:23](=[O:25])[NH:28][N:29]=4)[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 14071508HCID 14071508, Verbindung

Produkt 1

HCID 140715226-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

3.0 g (8 mmol) of 4-(2-benzenesulphonamido-indan-5-yl)-4-oxobutyric acid and 0.53 g (10.4 mmol) of 99% hydrazine hydrate in 12 ml of glacial acetic acid are boiled for 3 hours. The mixture is evaporated in vacuo, water is added to the residue, which is neutralised with sodium carbonate solution, and the reaction product is filtered off with suction and recrystallised from n-propanol.

Aufarbeitung

  1. customThe mixture is evaporated in vacuo, water
  2. additionis added to the residue, which
  3. filtrationthe reaction product is filtered off with suction
  4. customrecrystallised from n-propanol

Quellen und Nachweise

ORD-Eintrag
ord-2a89c6f2fa634af5816ac95578bbb7ad
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04820705

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