Acetic Acid → [4-(2-Ethyl-imidazo[4,5-c]quinolin-1-yl)-butyl]-(tetrahydro-thiophen-3-yl)-amine

HRID 62027

Reaktionsgleichung

Reaktionsgleichung von HRID 62027
[CH2:1]([C:3]1[N:4]([CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[CH:7][C:6]=2[N:15]=1)[CH3:2].C(O)(=O)C.[S:25]1[CH2:29][CH2:28][C:27](=O)[CH2:26]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>O1CCCC1>[CH2:1]([C:3]1[N:4]([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][CH:27]2[CH2:28][CH2:29][S:25][CH2:26]2)[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[CH:7][C:6]=2[N:15]=1)[CH3:2]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 61252Dihydro-3(2H)-thiophenoneHCID 5049666Sodium triacetoxyborohydrideHCID 223444144-(2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butan-1-amine

Produkt 1

HCID 67145397[4-(2-Ethyl-imidazo[4,5-c]quinolin-1-yl)-butyl]-(tetrahydro-thiophen-3-yl)-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of 4-(2-Ethyl-imidazo[4,5-c]quinolin-1-yl)-butylamine obtained in step VI in tetrahydrofuran was added acetic acid (1 eq.) and dihydrothiophen-3-one (1.1 eq.). Resulting reaction mixture was stirred for 10 min. Sodium triacetoxyborohydride (2.2 eq.) was added to reaction mixture over a period of 1 hrs and resulting suspension was then stirred for 4-5 hrs. Reaction was then quenched with methanol and concentrated to dryness. Reaction mixture was basified using aq.sodium hydroxide solution and extracted with chloroform. Organic layer was dried over sodium sulphate and concentrated under reduced pressure to yield sticky solid. Product was then purified by silica gel column chromatography to afford [4-(2-Ethyl-imidazo[4,5-c]quinolin-1-yl)-butyl]-(tetrahydro-thiophen-3-yl)-amine.

Aufarbeitung

  1. customResulting
  2. customreaction mixture
  3. customresulting suspension
  4. stirringwas then stirred for 4-5 hrs
  5. customReaction
  6. customwas then quenched with methanol
  7. concentrationconcentrated to dryness
  8. customReaction mixture
  9. extractionsodium hydroxide solution and extracted with chloroform
  10. dry with materialOrganic layer was dried over sodium sulphate
  11. concentrationconcentrated under reduced pressure
  12. customto yield sticky solid
  13. customProduct was then purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3b4acd6ddebe48b595fb987f1629eb35
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09446040B2

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