Acetic Anhydride → N-[(6-Methoxypyridin-2-yl)methyl]acetamide

HRID 621699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 621699
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[N:4]=1)#[N:2].[C:11]([O-])(=[O:13])[CH3:12].[Na+].C(OC(=O)C)(=O)C>[Ni]>[C:11]([NH:2][CH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[N:4]=1)(=[O:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 130236446-Methoxy-2-pyridinecarbonitrile

Produkt 1

HCID 13882972N-[(6-Methoxypyridin-2-yl)methyl]acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 935NickelKatalysator

Versuchsvorschrift

A mixture of 1.0 g (7.46 mmole) of 2-cyano-6-methoxypyridine, 0.37 g (4.48 mole) of sodium acetate, 25 ml of acetic anhydride and about 1.0 g of Raney nickel was hydrogenated on a Parr apparatus for about 5.5 hours. The mixture was filtered, and then evaporated with warming in vacuo to provide 2-acetamidomethyl-6-methoxypyridine. The structural assignment was supported by infrared spectral analysis.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customevaporated
  3. temperaturewith warming in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7464ff5199954099beafd8e15a1c8318
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04824953

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