N,N-Dimethylmethanesulphonamide → 1-(2-amino-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone
Reaktionsgleichung
[CH3:1][N:2]([CH3:7])[S:3]([CH3:6])(=[O:5])=[O:4].C([Li])CCC.[NH2:13][C:14]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:15]=1[C:16](OCC)=[O:17]>>[NH2:13][C:14]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:15]=1[C:16](=[O:17])[CH2:6][S:3](=[O:5])(=[O:4])[N:2]([CH3:7])[CH3:1]Komponenten
4
Versuchsvorschrift
In a similar manner to that described in Example 12(a), N,N-dimethylmethanesulphonamide was reacted with n-butyl lithium and the product was reacted with ethyl 2-amino-5-methoxybenzoate to give the novel compound 1-(2-amino-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone, m.p. 198°-200°.
Quellen und Nachweise
- ORD-Eintrag