Hydrochloric Acid → HCID 136252344, Verbindung

HRID 624550Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624550
C[O:2][C:3](=[O:32])[CH2:4][CH2:5][C:6]([NH:8][CH2:9][C:10]1[CH:31]=[CH:30][C:13]2[NH:14][C:15]3[S:16][C:17]([CH3:29])=[CH:18][C:19]=3[C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)=[N:21][C:12]=2[CH:11]=1)=[O:7].[Li+].[OH-].Cl>C1COCC1.O>[CH3:29][C:17]1[S:16][C:15]2[NH:14][C:13]3[CH:30]=[CH:31][C:10]([CH2:9][NH:8][C:6](=[O:7])[CH2:5][CH2:4][C:3]([OH:32])=[O:2])=[CH:11][C:12]=3[N:21]=[C:20]([N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[C:19]=2[CH:18]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 136377201HCID 136377201, Verbindung

Produkt 1

HCID 136252344HCID 136252344, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of N-[2-methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulen-7-ylmethyl]-succinamic acid methyl ester, prepared as described in the previous step, (80 mg, 0.18 mmol) in THF (1.5 mL) was added LiOH (14 mg) in water (0.5 mL). The solution was stirred at room temperature for 3 h, acidified with dilute HCl, and concentrated to dryness. LC-MS: m/z 442 (M+1 of the parent).

Aufarbeitung

  1. customprepared
  2. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-dc9fb150897f4cc0b7e922bf613d663e
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303041B2

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