2-Amino-5-bromobenzoic acid → HCID 178515323, Verbindung

HRID 627502

Reaktionsgleichung

Reaktionsgleichung von HRID 627502
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][C:13]([F:24])([F:23])[C:14](=O)[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CS(O)(=O)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O>[Br:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[C:14]([C:13]([F:23])([F:24])[F:12])[C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[C:4]2[OH:6]

Komponenten

5

Edukt 3

HCID 798582-Amino-5-bromobenzoic acidHCID 2229581,1,1-Trifluoro-3-phenyl-2-propanoneHCID 86584057Phosphorus Pentoxide-Methanesulfonic Acid

Produkt 1

HCID 178515323HCID 178515323, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2-amino-5-bromobenzoic acid (3.01 g, 13.9 mmol), 1,1,1-trifluoro-3-phenylpropan-2-one (3.11 g, 16.5 mmol), and Eaton's reagent (9.3 mL) in a sealed tube was heated at 100° C. for 4 hours. The reaction mixture was then allowed to cool to room temperature, water was added slowly, and the mixture was stirred vigorously for about 15 min. The precipitated solid was filtered, washed with water, and dried to give the title compound.

Aufarbeitung

  1. temperatureto cool to room temperature
  2. filtrationThe precipitated solid was filtered
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bc9ca85abd7b4788aa124e5e9ac7b94a
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09309222B2

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