Itaconic acid → 1-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid

HRID 632767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 632767
[Br:1][C:2]1[C:3]([NH2:8])=[N:4][N:5]([CH3:7])[CH:6]=1.O.[C:10]([OH:18])(=[O:17])[C:11]([CH2:13][C:14](O)=[O:15])=[CH2:12]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:3]([N:8]2[C:14](=[O:15])[CH2:13][CH:11]([C:10]([OH:18])=[O:17])[CH2:12]2)=[N:4][N:5]([CH3:7])[CH:6]=1

Komponenten

5

Edukt 3

HCID 811Itaconic acidHCID 962WaterHCID 27352834-bromo-1-methyl-1H-pyrazol-3-amine

Produkt 1

HCID 1180618811-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (312 mg) in a mixed solvent of water (2.0 mL) and toluene (2.0 mL) was added itaconic acid (245 mg). The reaction mixture was stirred at 120° C. for 5 hr, and the solvent was evaporated under reduced pressure. The residue was used for the next step without purification.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was used for the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-e2c31f9bde1545b2bcfda8189e8bfbc2
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321757B2

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