Hydroxyamine hydrochloride → 2-Fluoro-3-methoxybenzaldehyde oxime

HRID 632922Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 632922
C(=O)([O-])O.[Na+].Cl.[NH2:7][OH:8].[F:9][C:10]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:11]=1[CH:12]=O>O.C(O)C>[F:9][C:10]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:11]=1[CH:12]=[N:7][OH:8]

Komponenten

6

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 37744632-Fluoro-3-methoxybenzaldehyde

Produkt 1

HCID 762208362-Fluoro-3-methoxybenzaldehyde oximeAusbeute 85,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirred solution of sodium hydrogen carbonate (2.73 g, 32.5 mmol) in water (50 mL) was added hydroxylamine hydrochloride (2.30 g, 33.2 mmol) in portions over 30 min. The resultant solution was added to a vigorously stirred suspension of 2-fluoro-3-methoxybenzaldehyde (5.00 g, 32.5 mmol) in ethanol (45 mL) and the reaction mixture stirred at RT for 16 hr. The resultant precipitate was removed by filtration and washed with water (3×100 mL) and then allowed to dry in air to afford 2-fluoro-3-methoxybenzaldehyde oxime (14) (4.69 g, 85%) as a white crystalline solid: m/z 170 (M+H)+ (ES+).

Aufarbeitung

  1. customThe resultant precipitate was removed by filtration
  2. washwashed with water (3×100 mL)
  3. customto dry in air

Quellen und Nachweise

ORD-Eintrag
ord-a1ab1f1263504e928cc902a6c56cfaea
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321773B2

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