Trifluoroacetic acid → 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide

HRID 633000

Reaktionsgleichung

Reaktionsgleichung von HRID 633000
C([C:8]1[CH:16]=[C:15]([CH2:17][NH2:18])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=O)(OC(C)(C)C)=O.[Cl:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][C:21]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1.C(O)(C(F)(F)F)=O>O>[NH2:18][CH2:17][C:15]1[CH:16]=[CH:8][C:9]([C:10]([NH:24][C:23]2[CH:25]=[CH:26][C:20]([Cl:19])=[C:21]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)[CH:22]=2)=[O:12])=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 401519254-Chloro-3-(pyridin-2-yl)anilineHCID 66878017HCID 66878017, Verbindung

Produkt 1

HCID 668779924-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Procedure G was used to couple BOC-4-(aminomethyl)benzoic acid (48 mg) with 4-chloro-3-(pyridin-2-yl)aniline (35 mg). The crude reaction mixture was treated with TFA (1 mL) containing trace amounts of water for 1 h. The reaction mixture was concentrated to yield 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide.

Aufarbeitung

  1. customThe crude reaction mixture
  2. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-5465a48a4fa54ad49fe613e40b89cb13
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321761B2

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