Hydrogen Bromide → 1-Ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol

HRID 634910Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 634910
Br.[CH2:2]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[C:7]([CH3:15])=[CH:6][C:5]1([CH3:17])[CH3:16])[CH3:3].C([O-])(=O)C.[Na+].Br>O.C(Cl)(Cl)Cl>[CH2:2]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[C:7]([CH3:15])=[CH:6][C:5]1([CH3:16])[CH3:17])[CH3:3]

Komponenten

6

Edukt 3

HCID 260Hydrogen BromideHCID 517045Sodium AcetateHCID 21260952N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide

Produkt 1

HCID 154511031-Ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

200 g N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide was suspended in a mixture of 1 l water and 500 ml chloroform. 20% sodium acetate solution was added to this suspension until the pH value reached ca. 5. The organic phase was washed with water, dried over sodium sulfate and evaporated to dryness in a rotary evaporator. A light-brown oil was obtained in this manner. Since the released base decomposes very rapidly, only the required amount of base for the further process was released from the hydrobromide.

Aufarbeitung

  1. washThe organic phase was washed with water
  2. dry with materialdried over sodium sulfate
  3. customevaporated to dryness in a rotary evaporator
  4. customA light-brown oil was obtained in this manner

Quellen und Nachweise

ORD-Eintrag
ord-20f5b970b52d4e76a10484ba45fb3ed4
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06184379B2

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