Ethanol → 1-(2-Chloro-5-pyridylmethyl)-5-ethyl-2-nitroiminohexahydro-1,3,5-triazine

HRID 635172Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 635172
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]([NH:12][N+:13]([O-:15])=[O:14])=[NH:11])=[CH:4][N:3]=1.[CH2:16]([NH2:18])C.[CH2:19]=O.[CH2:21](O)[CH3:22]>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:16][N:18]([CH2:21][CH3:22])[CH2:19][NH:11][C:10]2=[N:12][N+:13]([O-:15])=[O:14])=[CH:4][N:3]=1

Komponenten

6

Edukt 4

HCID 702EthanolHCID 712FormaldehydeHCID 6341EthylamineHCID 178512104HCID 178512104, Verbindung

Produkt 1

HCID 1364010701-(2-Chloro-5-pyridylmethyl)-5-ethyl-2-nitroiminohexahydro-1,3,5-triazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirring mixture of 1 g of 1-(2-chloro-5-pyridylmethyl)-3-nitroguanidine, 0.28 g of 70% ethylamine in water and 20 ml of ethanol, 0.71 g of 37% formalin solution was added dropwise with heating. The reaction mixture was heated under reflux for two hours. After being allowed to cool to room temperature, the crystals formed, which were filtrated off and recrystallized from methanol to obtain 1.15 g of the title compound. This compound is No. 2 in Table 1. m.p.: 124-125° C.

Aufarbeitung

  1. additionwas added dropwise
  2. temperaturewith heating
  3. temperatureThe reaction mixture was heated
  4. temperatureunder reflux for two hours
  5. customthe crystals formed
  6. filtrationwhich were filtrated off
  7. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-9b8890ccb9ef4a74bfcb4ffe1e265c48
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06187773B1

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