Acetic Anhydride → N-(4-Iodophenyl)acetamide

HRID 635230

Reaktionsgleichung

Reaktionsgleichung von HRID 635230
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>C(Cl)Cl>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 108934-Iodoaniline

Produkt 1

HCID 12147N-(4-Iodophenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-Iodo-aniline (15 g, 69 mmol) in dry CH2Cl2 (100 ml) was added acetic anhydride(14.09 g, 138 mmol) at room temperature, the reaction mixture was then stirred for 2 hr. The gray color precipitate formed during the reaction was filtered, washed with ether and collected, the mother solution was concentrated to dryness and AcOEt was added, the resulting precipitate was filtered, washed with ether and combined with the previous solid as the desired product (15.95 g, 88.7%).

Aufarbeitung

  1. customThe gray color precipitate
  2. customformed during the reaction
  3. filtrationwas filtered
  4. washwashed with ether
  5. customcollected
  6. concentrationthe mother solution was concentrated to dryness and AcOEt
  7. additionwas added
  8. filtrationthe resulting precipitate was filtered
  9. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-00f4b8765ab64c0a831636bb8ed27486
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06187792B1

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