Potassium cyanate → N-[4-(5-Oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

HRID 637499

Reaktionsgleichung

Reaktionsgleichung von HRID 637499
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[O-:16][C:17]#[N:18].[K+]>O.CN(C)C1C=CN=CC=1>[NH:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1)[C:17]([NH2:18])=[O:16]

Komponenten

5

Edukt 2

HCID 11378442Potassium cyanateHCID 197942325-(4-Aminophenyl)-2(1H)-pyrazinone hydrochloride

Produkt 1

HCID 13853577N-[4-(5-Oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

5-(4-Aminophenyl)-2(1H)-pyrazinone hydrochloride (1.0 g) was dissolved in water (25 ml), to which solution potassium cyanate (0.4 g) and 4-dimethylaminopyridine (about 0.005 g) were added. The mixture was stirred at room temperature for 18 hours and the resulting suspended material collected by filtration. This was washed in hot dimethylformamide (30 ml), the insoluble material being collected and washed with water to afford the title compound, m.p.>300° C.; n.m.r. δ(DMSO-d6) 5.90 (s, 2H,--CONH2), 7.98, 8.10 (2d, 2H, pyridine H's); ν(liquid paraffin) 1710, 1665 cm-1.

Aufarbeitung

  1. additionwere added
  2. filtrationcollected by filtration
  3. washThis was washed in hot dimethylformamide (30 ml)
  4. customthe insoluble material being collected
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-589ded54d25d44fa9c663b2f6cd779eb
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04556711

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