Ethanol → N-Ethylisonicotinamide

HRID 638305

Reaktionsgleichung

Reaktionsgleichung von HRID 638305
C(O)C.[CH2:4]([NH2:6])[CH3:5].[C:7](OC)(=[O:14])[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1>O>[CH2:4]([NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)[CH3:5]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 6341EthylamineHCID 227085Methyl isonicotinate

Produkt 1

HCID 571600N-Ethylisonicotinamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 200 ml of ethanol and 20 ml water was cooled in an ice bath and saturated with ethylamine for 0.5 hr. then 80 g of crude methyl isonicotinate was added with cooling. Ethylamine was again bubbled onto the reaction mixture for 10 min and then it was allowed to stand overnight at room temperature. It was then concentrated in vacuo to leave 82.82 g of a pale oil which became semisolid on cooling.

Aufarbeitung

  1. temperaturewith cooling
  2. customEthylamine was again bubbled onto the reaction mixture for 10 min
  3. concentrationIt was then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9cbaf1315d844d779728f10b59c9163a
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04560692

Verknüpfte Notizen

Wird geladen…