Sulfuric Acid → HCID 12674764, Verbindung

HRID 638306Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 638306
[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][CH:6]=[CH:5]1.S(=O)(=O)(O)O.N1C=CC=C1.[C:19](Cl)(=[O:21])[CH3:20].C(OC(=O)C)(=O)C>C(O)(=O)C>[C:19]([O:1][CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][CH:6]=[CH:5]1)(=[O:21])[CH3:20]

Komponenten

7

Edukt 5

HCID 1118Sulfuric AcidHCID 6367Acetyl chloride2×HCID 7918Acetic Anhydride2×HCID 8027PyrroleHCID 109754381-(2-Hydroxyethyl)pyrrole2×

Produkt 1

HCID 12674764HCID 12674764, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Once the 1-(2-hydroxyethyl)pyrrole is obtained, it is esterified by any suitable means known in the art. For example, acetic acid is reacted with the 1-(2-hydroxyethyl)pyrrole in the presence of a strong acid such as sulfuric acid, and the reaction mixture is heated sufficiently to distill off the water that is formed as a result of the reaction. Preferably however, the pyrrole is reacted with acetyl chloride or acetic anhydride in a suitable solvent wherein there is a molar excess of the acetyl chloride or acetic anhydride. This reaction takes place at room temperature and will be completed in a relatively short period of time, with only an hour or two at the most being required for the reaction to reach completion. The 1-(2-acetoxyethyl)pyrrole is then isolated and purified by any means known in the art, such as extraction with a suitable organic solvent and removal of the solvent, to yield the desired compound represented by Formula (3).

Aufarbeitung

  1. temperaturethe reaction mixture is heated sufficiently
  2. distillationto distill off the water that
  3. customis formed as
  4. customa result of the reaction
  5. customat room temperature
  6. waitwill be completed in a relatively short period of time, with only an hour
  7. customtwo at the most being required for the reaction

Quellen und Nachweise

ORD-Eintrag
ord-4e2442e08a1341dd8bb8aee103845cde
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04560699

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