Bromine → 6-Bromo-2-nitropyridin-3-ol

HRID 639052

Reaktionsgleichung

Reaktionsgleichung von HRID 639052
[OH:1][C:2]1[C:3]([N+:8]([O-:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.C[O-].[Na+].[Br:14]Br>CO>[Br:14][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([N+:8]([O-:10])=[O:9])[N:4]=1

Komponenten

5

Edukt 3

HCID 24408BromineHCID 270573-Hydroxy-2-nitropyridineHCID 10942334Sodium Methoxide

Produkt 1

HCID 218738086-Bromo-2-nitropyridin-3-olAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

3-Hydroxy-2-nitropyridine (20 g, 0.143 mole) was dissolved in methanol (400 mL) and a solution of 25% sodium methoxide in methanol (33 mL, 0.13 mole) was added at room temperature. The mixture was stirred for 30 min, then was cooled to 0° C., and bromine (7.2 mL, 0.14 mole) was added slowly. The reaction was stirred at 0° C. for 30 min, then was quenched with glacial AcOH (2.5 mL). The solvent was removed in vacuo to afford material (30 g, 96%), which was used without further purification.

Aufarbeitung

  1. stirringThe reaction was stirred at 0° C. for 30 min
  2. customwas quenched with glacial AcOH (2.5 mL)
  3. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cdac4f8bfadb4d43b5e32cb834e0c950
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691850B2

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