4-Aminobenzoic acid hydrazide → HCID 178507641, Verbindung

HRID 642044

Reaktionsgleichung

Reaktionsgleichung von HRID 642044
[I:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.[NH2:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([NH:20][NH2:21])=[O:19])=[CH:16][CH:15]=1>C(O)(=O)C>[NH2:13][C:14]1[CH:23]=[CH:22][C:17]([C:18]([NH:20][N:21]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([I:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[O:19])=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 214504-Aminobenzoic acid hydrazideHCID 886955-Iodoisatin

Produkt 1

HCID 178507641HCID 178507641, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-aminobenzohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 395 mg of the title compound (97%) as a yellow solid in 99.2% purity by HPLC (Rt: 4.41, gradient of 10 min, MaxPlot detection between 230 and 400 nm).

Aufarbeitung

  1. temperaturethe reaction mixture was cooled to rt
  2. customa yellow solid precipitated out
  3. filtrationFiltration on a fritté
  4. washwashing with AcOH, water
  5. customdrying under vacuo at 60° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-c63f29eb913044d1b6b2028dd5d9d71d
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696231B2

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