Water → HCID 21555860, Verbindung

HRID 643285Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 643285
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13].O.[OH-].[NH4+:22]>>[NH2:22][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]

Komponenten

4

Edukt 3

HCID 962WaterHCID 14923Ammonium HydroxideHCID 27375522-Fluoro-3-(trifluoromethyl)benzophenone

Produkt 1

HCID 21555860HCID 21555860, VerbindungAusbeute 90 %

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

A suspension of (2-fluoro-3-trifluoromethyl-phenyl)-phenyl-methanone (0.5 g, 1.87 mmol) in 10 ml of ammonium hydroxide (28%) was sealed in a heavy-welled Pyrex tube. The sealed tube was heated at 140° C. overnight. The reaction was poured into water/saturated ammonium chloride solution and extracted with ethyl acetate. The combined organics was dried over MgSO4 and concentrated to give (2-amino-3-trifluoromethyl-phenyl)-phenyl-methanone as an oil (0.45 g, 90%). MS ESI (m/z) 266 ([M+H]+);

Aufarbeitung

  1. customwas sealed in a heavy-welled Pyrex tube
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organics was dried over MgSO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-613f98253c564c3ca993aff978fd0223
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700595B2

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