Lithium Hydroxide → 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

HRID 643686

Reaktionsgleichung

Reaktionsgleichung von HRID 643686
[NH2:1][C:2]1[C:7]([C:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[OH-].[Li+]>CO.O>[NH2:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[C:4]([S:11][CH3:12])[N:3]=1

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 225621764-Amino-2-methylsulfanyl-5-pyrimidinecarboxylate

Produkt 1

HCID 221347384-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

4-Amino-2-methylmercaptopyrimidine-5-carboxylate (1.5 g, 7 mmol) was suspended in the solution of lithium hydroxide (340 mg, 14 mmol) in methanol (10 mL) and water (5 mL) and stirred at 60° C. over night. Solid was filtered out and filtrate was collected. Solvent was removed under reduce pressure. Residue was dissolved in water and was neutralized by acetic acid till pH˜5. White solid thus formed was filtered out and dried in vacuo (0.72 g, 55%).

Aufarbeitung

  1. filtrationSolid was filtered out
  2. customfiltrate was collected
  3. customSolvent was removed
  4. dissolutionResidue was dissolved in water
  5. customWhite solid thus formed
  6. filtrationwas filtered out
  7. customdried in vacuo (0.72 g, 55%)

Quellen und Nachweise

ORD-Eintrag
ord-dfeec2a9bec54db3837328b45d7212e2
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700622B2

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