Ammonium Hydroxide → Levobupivacaine

HRID 643763Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 643763
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.C(C(C(C([O-])=O)O)O)([O-])=O.[OH-].[NH4+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 86591002Levobupivacaine tartrate

Produkt 1

HCID 92253Levobupivacaine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

45 g of levobupivacaine tartrate were dissolved in 222 mL of water under stirring. Concentrated ammonium hydroxide was added under stirring until the pH adjusted at 9-10. The solids were filtered and washed with 222 mL of water. The solids were dried in an oven with temperature around 45° C. until constant weight. Yield 27.6 g of enriched levobupivacaine free base (70%≦ee≦80%), MP=125-132° C.

Aufarbeitung

  1. stirringunder stirring until the pH
  2. filtrationThe solids were filtered
  3. washwashed with 222 mL of water
  4. customThe solids were dried in an oven with temperature around 45° C. until constant weight

Quellen und Nachweise

ORD-Eintrag
ord-73b4d2ebe2184472a1829a8c3c010dc1
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700629B2

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