Reaktionsgleichung
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](OC2C=CC=CC=2)=[CH:6][CH:5]=1)=[O:3].[Br:17]Br>>[Br:17][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3]Komponenten
3
Versuchsvorschrift
4-Phenoxyacetophenone was brominated with bromine according to Method A to provide the desired α-bromoacetophenone, which was condensed with 2-amino-13,4,-thiadiazole-5-sulfonamide according to method C, to provide compound 87 as an off white solid. 1H NMR (200 MHz, DMSO-d6) δ 8.82 (s, 1H), 8.71 (s, 2H), 7.90 (d, J=7.9 Hz, 2H), 7.40 (t, J=7.3 Hz, 2H), 7.07 (t, J=7.3 Hz, 1H), 7.08-7.03 (m, 6H).
Quellen und Nachweise
- ORD-Eintrag
- ord-6b2f4daf251742cab4bba3f399a3f7ee
- Quelldatensatz
- uspto-grants-2010_04
- Patentnummer
- US07700635B2
Verknüpfte Notizen
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