Chloroacetaldehyde → HCID 178518393, Verbindung

HRID 645669Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 645669
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[C:10]([O-])(=O)[CH3:11].[Na+].ClCC=O>O>[N:7]1[C:2]2[NH:1][CH:10]=[CH:11][C:3]=2[C:4]([OH:9])=[N:5][C:6]=1[OH:8]

Komponenten

5

Edukt 3

HCID 33ChloroacetaldehydeHCID 701206-AminouracilHCID 517045Sodium Acetate

Produkt 1

HCID 178518393HCID 178518393, VerbindungAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a suspension of 6-aminouracil (15 g, 0.118 mol) in H2O (600 mL) was added sodium acetate (NaOAc) (15 g, 0.183 mol) and chloroethanal (ClCH2CHO) (50% in H2O, 30 mL). The mixture was heated at reflux for 4 h and then cooled to room temperature. The resulting dark brown precipitates were collected by filtration to afford crude 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol (14.4 g, 81% yield).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 h
  3. customThe resulting dark brown precipitates
  4. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b01a04c2081f4385a7d77e841ea49ad2
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705004B2

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