Piperazine → Molracetam

HRID 64869

Reaktionsgleichung

Reaktionsgleichung von HRID 64869
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:8])=[CH:5][CH:4]=1.N1CCNCC1.C(Cl)(=O)C1C=CC(OC)=CC=1.Cl[CH2:35][C:36]([N:38]1[CH2:43][CH2:42][O:41][CH2:40][CH2:39]1)=[O:37].N1CCOCC1.ClCC(Cl)=O>C(O)(=O)C.C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]2[CH2:14][CH2:13][N:12]([CH2:35][C:36]([N:38]3[CH2:43][CH2:42][O:41][CH2:40][CH2:39]3)=[O:37])[CH2:11][CH2:10]2)=[O:8])=[CH:15][CH:16]=1

Komponenten

9

Edukt 6

HCID 4837PiperazineHCID 6577Chloroacetyl chlorideHCID 7477p-Anisoyl chlorideHCID 8083MorpholineHCID 74040Morpholine, 4-(chloroacetyl)-HCID 27367241-(4-Methoxybenzoyl)-piperazine

Produkt 1

HCID 779179Molracetam

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

The N-(4-methoxybenzoyl)-piperazine used as a starting substance was obtained as a viscous oil by reacting 1 mol of piperazine with 0.5 mol of anisic acid chloride in glacial acetic acid. The chloroacetic acid morpholide used as a starting substance was obtained as a colourless oil by reacting 2 mol of morpholine with 1 mol of chloroacetyl chloride in toluene.

Aufarbeitung

  1. customwas obtained as a viscous oil
  2. customwas obtained as a colourless oil

Quellen und Nachweise

ORD-Eintrag
ord-20e6d607f1b54f2496f4bc6be8b34c54
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04610984

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