C([BH3-])#N.[Na+].[C:5]([C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([CH3:20])[CH2:17][NH:18][CH3:19])=[CH:11][CH:10]=1)([CH3:8])([CH3:7])[CH3:6].[CH:21]([C:23]1[CH:24]=[N:25][N:26]([CH3:28])[CH:27]=1)=O.C(O)(=O)C>CO>[C:5]([C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([CH3:20])[CH2:17][N:18]([CH2:21][C:23]2[CH:24]=[N:25][N:26]([CH3:28])[CH:27]=2)[CH3:19])=[CH:13][CH:14]=1)([CH3:8])([CH3:6])[CH3:7]Route B-2: After suspending 200 mg (3.2 mmol) of sodium cyanoborohydride in 2 ml of absolute methanol, 380 mg (1.7 mmol) of 3-(4-t-butylphenyl)-N,2-dimethylpropylamine (IV-1) was added thereto. Subsequently, to this was added a solution of 170 mg (1.6 mmol) 4-formyl-1-methylpyrazole/2 ml absolute methanol by portions, the pH was adjusted to 7 with acetic acid, and then stirring was conducted at room temperature for 8 h.
Wird geladen…