Indene → 2-[3,5-Bis(trifluoromethyl)phenyl]-1H-indene

HRID 650304Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 650304
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.I[C:11]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=1>CC([O-])=O.CC([O-])=O.[Pd+2].C(N(CC)CC)C>[F:18][C:17]([F:19])([F:20])[C:15]1[CH:16]=[C:11]([C:2]2[CH2:3][C:4]3[C:9]([CH:1]=2)=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH:12]=[C:13]([C:21]([F:22])([F:23])[F:24])[CH:14]=1

Komponenten

5

Edukt 2

HCID 7219IndeneHCID 6309701-Iodo-3,5-bis(trifluoromethyl)benzene

Produkt 1

HCID 120106252-[3,5-Bis(trifluoromethyl)phenyl]-1H-indene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 167845palladium(II) acetateKatalysatorHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

20 ml of triethylamine, 2.2 g (20 mmole) of indene, 6.8 g (20 mmole) of 1-iodo-3,5-bis(trifluoromethyl)-benzene and 0.134 g (0.6 mmole) and 0.134 g (0.6 mmole) of Pd(OAc)2 were stirred under relux for 12 h. After it all triethylamine was removed under reduced pressure. The residue was treated with the mixture 50 ml of water and 50 ml of diethyl ether.

Aufarbeitung

  1. customAfter it all triethylamine was removed under reduced pressure
  2. additionThe residue was treated with the mixture 50 ml of water and 50 ml of diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f1e9133ef0e54f7295b0c949d591a90e
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06271411B1

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