Methanol → Boc-Phe-Gly-OH

HRID 652379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 652379
[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([O:16]CC1C=CC=CC=1)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CO>[Pd].CC(O)=O>[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([OH:16])=[O:15])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 15601613HCID 15601613, Verbindung

Produkt 1

HCID 7014899Boc-Phe-Gly-OHAusbeute 92,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Boc-Phe-Gly-OBzl (6.2 g, 15 mmole) was suspended in the mixtured solvent of MeOH (80 ml) and AcOH (30 ml), and then H2 gas was passed through the solution in the presence of Pd-C for 4 hours. Pd-C was removed by filtration, and the solvent was distilled off. The thus-obtained residue was recrystalized two times with AcOEt/n-hexane to obtain the object product (4.49 g, 92.8%).

Aufarbeitung

  1. customPd-C was removed by filtration
  2. distillationthe solvent was distilled off
  3. customThe thus-obtained residue was recrystalized two times with AcOEt/n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-775688068557490fb481461376de20d4
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670540

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