Pyridinium chloride → HCID 13290001, Verbindung

HRID 652622Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 652622
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[C:15]([O:17]C)[C:14]([Cl:19])=[C:13]([Cl:20])[C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>O>[Cl:19][C:14]1[C:15]([OH:17])=[CH:16][C:9]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[CH:12][S:11][C:10]=2[C:13]=1[Cl:20]

Komponenten

4

Edukt 2

HCID 10176127Pyridinium chlorideHCID 13289998HCID 13289998, Verbindung

Produkt 1

HCID 13290001HCID 13290001, VerbindungAusbeute 78,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 200 mg of 3-(4-chlorophenyl)-6,7-dichloro-5-methoxybenzo[b]thiophene and 1.77 g of pyridine hydrochloride is stirred and heated at 195°-205° for two and one half hours. The reaction is cooled and 20 ml of water is added. The resulting solid is collected on a filter and washed with 1N hydrochloric acid. The product is chromatographed on a silica gel-hexane column using 3:1 hexane/ether as elutent. The product is isolated and recrystallized from acetone-hexane to give 150 mg of 6,7-dichloro-3-(4-chlorophenyl)-5-hydroxybenzo[b]thiophene as a white powder, mp 174°-176°.

Aufarbeitung

  1. temperatureheated at 195°-205° for two and one half hours
  2. temperatureThe reaction is cooled
  3. customThe resulting solid is collected on
  4. filtrationa filter
  5. washwashed with 1N hydrochloric acid
  6. customThe product is chromatographed on a silica gel-hexane column
  7. customThe product is isolated
  8. customrecrystallized from acetone-hexane

Quellen und Nachweise

ORD-Eintrag
ord-4cd8df0ad8964c32a770aa944fd7efec
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04672138

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