Phosphoric Acid → Sodium 3-phenylacetamido-2-oxoazetidine-1-sulfonate

HRID 653235Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 653235
[NH2:1][CH:2]1[CH2:5][N:4]([S:6]([OH:9])(=[O:8])=[O:7])[C:3]1=[O:10].[C:11]1([CH2:17][C:18](Cl)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(=O)([O-])O.[Na+:25].P(=O)(O)(O)O>O.O1CCCC1>[C:11]1([CH2:17][C:18]([NH:1][CH:2]2[CH2:5][N:4]([S:6]([O-:9])(=[O:8])=[O:7])[C:3]2=[O:10])=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Na+:25]

Komponenten

7

Edukt 4

HCID 1004Phosphoric AcidHCID 7679Phenylacetyl chlorideHCID 516892Sodium BicarbonateHCID 130190953-Amino-2-oxoazetidine-1-sulfonic acid

Produkt 1

HCID 23695024Sodium 3-phenylacetamido-2-oxoazetidine-1-sulfonateAusbeute 45,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

In 1 ml of water is dissolved 50 mg of the above 3-amino 2-oxoazetidine-1-sulfonic acid, followed by addition of a solution of 69 mg of phenylacetyl chloride in 1 ml tetrahydrofuran and 101 mg of sodium hydrogen carbonate in alternate portions with ice-cooling and stirring. After stirring at room temperature for 30 minutes, the mixture is adjusted to pH 5.8 with phosphoric acid. The tetrahydrofuran is then distilled off under reduced pressure. The water layer is washed with ethyl acetate and purified by XAD-II chromatography, whereby 42 mg of sodium 3-phenylactamido-2-oxoazetidine-1-sulfonate is obtained.

Aufarbeitung

  1. temperaturecooling
  2. stirringAfter stirring at room temperature for 30 minutes
  3. distillationThe tetrahydrofuran is then distilled off under reduced pressure
  4. washThe water layer is washed with ethyl acetate
  5. custompurified by XAD-II chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2aae10082a62410b9d20b37e9075f079
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04675397

Notizen zur Reaktion

Wird geladen…