Water → (2,3-Dihydro-1-benzofuran-2-yl)methanol

HRID 654752

Reaktionsgleichung

Reaktionsgleichung von HRID 654752
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][CH:8]1[C:16](O)=[O:17].O.[OH-].[Na+]>C(OCC)C>[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][CH:8]1[CH2:16][OH:17]

Komponenten

6

Edukt 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 27765552,3-Dihydro-1-benzofuran-2-carboxylic acidHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 2795428(2,3-Dihydro-1-benzofuran-2-yl)methanolAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

A three-necked flask is charged with 17 g of lithium aluminum hydride dissolved in anhydrous ethyl ether. 3 g of 2,3-dihydro-2-benzofurancarboxylic acid (Chim. Ler., (1973), 3, p. 259), dissolved in 1,140 ml of ethyl ether, are then introduced. The reaction medium is left stirring overnight. It is then hydrolyzed in an ice bath with 15.2 ml of water, 15.2 ml of 4N sodium hydroxide and then 45.2 ml of water. The complex is drained and washed with ethyl ether and the filtrate is dried and distilled to obtain the expected compound

Aufarbeitung

  1. additionare then introduced
  2. waitThe reaction medium is left
  3. washwashed with ethyl ether
  4. customthe filtrate is dried
  5. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-e7dd00e04394442096bec33f41038b65
Quelldatensatz
uspto-grants-1992_07
Patentnummer
US05134147

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