Isopropanol → 2-Cyclohexen-1-one, 2,5,6-trimethyl-

HRID 65802

Reaktionsgleichung

Reaktionsgleichung von HRID 65802
O[CH:2]([CH3:6])[CH2:3][CH:4]=[O:5].[CH2:7]([C:9]([CH2:11]C)=O)[CH3:8].[CH:13](O)(C)C.[OH-].[Na+]>C(O)(=O)C>[CH3:13][C:3]1[C:4](=[O:5])[CH:7]([CH3:8])[CH:9]([CH3:11])[CH2:6][CH:2]=1

Komponenten

6

Edukt 4

HCID 3776IsopropanolHCID 7288Ethyl ketone2×HCID 78973-HydroxybutanalHCID 14798Sodium Hydroxide

Produkt 1

HCID 892642-Cyclohexen-1-one, 2,5,6-trimethyl-Ausbeute 47,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 88 g of β-hydroxybutyraldehyde and 150 g of diethyl ketone is added dropwise in the course of one hour to a mixture of 250 g of diethyl ketone, 80 g of isopropanol and 5 g of sodium hydroxide powder which is boiling under reflux. The whole is boiled for another hour under reflux. Neutralization is effected with glacial acetic acid and the aqueous phase is separated. The organic layer is fractionated. 65 g of 2,5,6-trimethyl-2-cyclohexen-1-one having a boiling point of 74° to 76° C. at 12 mm Hg is obtained. The yield is 47% with reference to β-hydroxybutyraldehyde.

Aufarbeitung

  1. temperatureunder reflux
  2. waitThe whole is boiled for another hour
  3. temperatureunder reflux
  4. customthe aqueous phase is separated

Quellen und Nachweise

ORD-Eintrag
ord-c16defd56be34a8fba979fa521f18f93
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04128728

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