2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid

HRID 660342

Reaktionsgleichung

Reaktionsgleichung von HRID 660342
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1

Komponenten

5

Edukt 1

HCID 892442-(4-Nitrophenyl)propionic acid

Produkt 1

HCID 430264-Aminohydratropic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 1 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.

Aufarbeitung

  1. customat room temperature
  2. filtrationThe mixture is filtered through celite pad
  3. washwashed with EtOH
  4. concentrationThe filtrate is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fdc8fedb933d421686298bc443ce1c81
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084484B2

Verknüpfte Notizen

Wird geladen…