2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid
Reaktionsgleichung
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1Komponenten
5
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
A mixture of 1 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.
Aufarbeitung
- customat room temperature
- filtrationThe mixture is filtered through celite pad
- washwashed with EtOH
- concentrationThe filtrate is concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-fdc8fedb933d421686298bc443ce1c81
- Quelldatensatz
- uspto-grants-2011_12
- Patentnummer
- US08084484B2
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