C[O:2][C:3](=[O:25])[CH2:4][N:5]1[C:9](=[O:10])[N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[C:7]([C:19]2[S:20][C:21]([Cl:24])=[CH:22][CH:23]=2)=[N:6]1.[OH-].[Li+].O>CO>[Cl:24][C:21]1[S:20][C:19]([C:7]2[N:8]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[C:9](=[O:10])[N:5]([CH2:4][C:3]([OH:25])=[O:2])[N:6]=2)=[CH:23][CH:22]=12.90 g (7.60 mmol) of the ester from Example 153A are dissolved in 77 ml methanol and treated with a 1 N solution of lithium hydroxide in water (30.3 ml, 30.4 mmol). The mixture is stirred overnight at RT, then freed of methanol on the rotary evaporator and diluted with 200 ml water. After addition of 1 N hydrochloric acid to a pH value of 2, the product precipitates out as a white solid, which is isolated by filtration and drying in high vacuum. 2.45 g (88% of theory) of the title compound are obtained.
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