4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl ester → HCID 53707130, Verbindung

HRID 66147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66147
[CH2:1]([O:3][C:4]([C:6]1[N:11]([CH2:12][C:13]#[CH:14])[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][C:22]#[CH:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])[CH3:2].[H][H]>[Pd].C(O)(=O)C>[CH2:1]([O:3][C:4]([C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])[CH3:2]

Komponenten

5

Edukt 2

HCID 544541564,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 53707130HCID 53707130, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (20 g, described in Example 20), 5% palladium on charcoal (2.0 g) and acetic acid (400 ml) is stirred rapidly under an atmosphere of hydrogen until 5.7 liters of hydrogen are absorbed. The mixture is filtered and the filtrate is evaporated. The residue is subjected to chromatography on silica gel using acetone-hexane (1:1). The eluates are evaporated to give a residue of the title compound.

Aufarbeitung

  1. customare absorbed
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated
  4. customThe eluates are evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a9d8d5c7c1394be18af0176ae4a3c433
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04130649

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