Acetone → 2-(2-Methylsulfinylphenyl)oxazolo[4,5-b]pyridine

HRID 66357Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66357
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]2[C:12]([N:17]=1)=[N:13][CH:14]=[CH:15][CH:16]=2.CC(C)=[O:20].I([O-])(=O)(=O)=O.[Na+]>O>[CH3:1][S:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]2[C:12]([N:17]=1)=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:20]

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 124613832-(2-(Methylthio)phenyl)oxazolo[4,5-b]pyridineHCID 23667635Sodium periodate

Produkt 1

HCID 227547742-(2-Methylsulfinylphenyl)oxazolo[4,5-b]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 0.5 g. of 2-(2-methylthiophenyl)oxazolo[4,5-b]pyridine in 50 ml. of acetone was treated with 3 g. of sodium metaperiodate. After stirring over the weekend at room temperature, the mixture was diluted with 30 ml. of water. The acetone was distilled out and the resulting precipitate was recrystallized to give 2-(2-methylsulfinylphenyl)oxazolo[4,5-b]pyridine, m.p. 153.5°-155.5° C.

Aufarbeitung

  1. additionthe mixture was diluted with 30 ml
  2. distillationThe acetone was distilled out
  3. customthe resulting precipitate was recrystallized

Quellen und Nachweise

ORD-Eintrag
ord-548d223cad3b4458973ef2116fdf6cae
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04131677

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