Acetic Anhydride → N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]formamide

HRID 67904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 67904
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:16])C)=[N:9]2)[CH:5]=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>C(O)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:16])=[N:9]2)[CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 13050983N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]acetamide

Produkt 1

HCID 13050984N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]formamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

A mixture of 5.0 g. of 2-(3-amino-2-pyrazolin-1-yl)-6-chloropyridine (prepared as described in Example 3) and 25 ml. of a mixture of formic acid and acetic anhydride (Feiser and Feiser, Reagents for Organic Synthesis, Vol. 1, page 4) at room temperature gives an immediate yellow precipitate. The precipitate is collected by filtration then is recrystallized from acetone-hexane to give 3.05 g. of the product of the Example as off-white crystals, m.p. 190°-192° C.

Aufarbeitung

  1. additionA mixture of 5.0 g
  2. customgives an immediate yellow precipitate
  3. filtrationThe precipitate is collected by filtration
  4. customthen is recrystallized from acetone-hexane
  5. customto give 3.05 g

Quellen und Nachweise

ORD-Eintrag
ord-b3c9d641736e4e999de7ec8af81e9585
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04347251

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